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“CBD is a potent anti-inflammatory and can decrease joint pain in patients with arthritis and other conditions that cause joint inflammation. Patients often report better mobility and an ability to decrease the use of NSAIDs with CBD use. Another study, published in the journal Pain, focused on CBD pain prevention in relation to rat osteoarthritis. Upon studying osteoarthritis in rats, it was found that CBD blocked joint pain in a dose-dependent manner. In addition, prophylactic CBD administration prevented the future development of nerve damage and associated pain in the arthritic joints.

It was found that the application of CBD significantly reduced joint swelling, as well as limb posture scores as a rating of pain. It was concluded that topical CBD offers therapeutic potential for pain-related inflammation and behaviors associated with arthritis. In animal studies, CBD has been shown to reduce inflammation and relieve joint pain without inducing significant side effects. However, human studies are limited, and the results are mixed.

The researchers concluded that CBD may be a safe treatment option in mammals, targeting pain while blocking the inflammatory responses that drive disease progression. A 2016 study, published in the European Journal of Pain, examined the efficacy of topical CBD in rats.

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Based on the ways in which CBD oil impacts key brain receptors, it shows promise for those seeking an alternative treatment option in the hopes of reducing pain and inflammation. It may also address conditions related to chronic pain, including anxiety and sleep disorders. Most people find taking a serving of mg one to two times a day to be beneficial, though you could see improvements even after much smaller amounts. However, the optimal amount and frequency of servings can vary person to person.

  • A recent study shows that certain components in low testosterone cannabis may help reduce inflammation associated with alcohol use and serious liver health issues.
  • This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects of marijuana or certain pharmaceutical drugs.
  • It’s gaining momentum in the health and wellness world, with some scientific studies confirming it may ease symptoms of ailments like chronic pain and anxiety.

From there, the CBD is transported by the blood to the liver where it enters the liver via the hepatic portal. Once the CBD is in the liver, it is broken down into its metabolites by enzymes after which it can be circulated throughout the body in the bloodstream.

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Just like food has to go through this process, so too does a therapeutic compound such as CBD, but in what is more specifically called drug metabolism. However, despite the fact that the vast majority of the science indicates CBD oil is safe to use on its own, CBD is a powerful compound that interacts with a variety of systems within the body. And as such, CBD not only shows potential as a powerful therapeutic agent, but can become less benign when taken together with other substances such as pharmaceutical drugs. “I’ve been prescribing medical cannabis to patients in my pain practice, hundreds of them, for about 10 years,” Williams says. Dr. Bonni Goldstein is a medical adviser to Weedmaps.com, author of Cannabis Revealed, and Medical Director of Canna-Centers in California.

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It is estimated that the CYP system is responsible for metabolizing over 60% percent of any drug that has been consumed. And interestingly, pharmaceutical researchers and doctors also use cytochrome P450 system to understand, calculate and predict drug dosages, effects as well as its potential side effects. So, when CBD is ingested by mouth, either as an oil, tincture, capsule or edible, it has to pass through the digestive system where the it is absorbed into the bloodstream by the intestines.

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